Clinical PET/MRI Work Package 2:

Diagnostic assessment of amino acid PET/MRI in the evaluation of glioma and brain metastases

MRI is used in clinical routine for diagnosing brain tumors, but has limitations in identifying tumor grade, true tumor extension and differentiating viable tumor tissue from treatment induced changes and recurrences.

Many brain tumors express increased levels of amino acid transport, which can be imaged with a PET scanner using amino acid radiotracers. Using both MRI and PET will likely improve brain tumor diagnostics, resection, tissue sampling, treatment planning and therapy response assessment significantly.

In this study, combined PET/MRI and three of the most promising amino acid tracers (11C-MET, 18F-FET and 18F-FACBC) will be evaluated, with the aim to improve diagnostic accuracy in cerebral gliomas and brain metastases, at primary diagnosis and follow-up.

Live Eikenes

Principal Investigator

Anna Karlberg

Principal Investigator

Work package 1:

1 in 8 men will have prostate cancer in their lives. Molecular imaging may offer huge benefits in all stages of the diagnostic work-up, and PET imaging using the tracer prostate specific membrane antigen (PSMA) has shown promising results. This WP aims to establish nation-wide protocols for PSMA-PET (in combination with hybrid MRI or CT)…

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Work package 2:

MRI is used in clinical routine for diagnosing brain tumors, but has limitations in identifying tumor grade, true tumor extension and differentiating viable tumor tissue from treatment induced changes and recurrences. Many brain tumors express increased levels of amino acid transport, which can be imaged with a PET scanner using amino acid radiotracers. Using both…

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Work package 3:

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Work package 4:

In WP4 we will establish the clinical workflow for PET- and MRI-based radiotherapy. We will acquire PET and MR images prior to and during radiotherapy and develop new concepts for image-based biologically adaptive radiotherapy, both based on state-of-the-art photon-based radiotherapy and also proton therapy, which soon will be available for cancer patients in Norway. Our…

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Work package 5:

In the machine learning work package, we aim to develop and validate new methods that exploit the quantitative nature of the PET and MR images. We will develop a pipeline for pre-processing and quality assurance of the acquired images, as well as a toolbox with machine learning algorithms focusing on region classification and detection of…

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