Bergen

WP4: Tracer Implementation

By kjm / 3. October 2020 / Comments Off on WP4: Tracer Implementation

Development of new tracers takes on average 13 years, similar to other pharmaceuticals. In order to increase patient care and precision diagnostics during the timeframe of this project, much attention will be given to WP4 “Tracer Implementation” to increase the number of locally available PET tracers. Due to the aforementioned costs associated with transport and…

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WP3: Targeting tyrosine kinases for development of novel selective radioendotheranostics for glioblastoma

By kjm / 3. October 2020 / Comments Off on WP3: Targeting tyrosine kinases for development of novel selective radioendotheranostics for glioblastoma

This work package will draw the current consortium wide expertise in kinase inhibitors (KIs) and jointly develop small molecule KIs for imaging and treatment of brain tumors. To achieve our goals we will utilize a dual strategy: Development of novel KIs radiolabeled with 11C and 18F and development of novel bioconjugates containing a therapeutic radiometal.…

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WP 2: Metal Chelators and Immuno-PET tracers

By kjm / 3. October 2020 / Comments Off on WP 2: Metal Chelators and Immuno-PET tracers

Radiolabeling with the promising radionuclide 45Ti and their immobilization on relevant peptides and development of peptide-chelator conjugates for immuno-PET imaging applications will be in focus. We are aiming to implement an efficient method for 45Ti isotope trapping via diol- functionalized resins, subsequently study the decomplexation of resin-bound 45Ti by wrapping the titanium with multidentate and…

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WP1: Precursor and Radiolabeling Methodology

By kjm / 3. October 2020 / Comments Off on WP1: Precursor and Radiolabeling Methodology

In WP1 “Precursor and Radiolabeling Methodology” we will use contemporary organic synthesis strategies for preparing facile radiolabeling substituents. This will include catalytic functionalization for 18F or 11C labeling, solid supported resin-bound methods and other late stage functionalization strategies. The strategies explored here will also be developed into methods for instrumental radiolabeling using current radiosynthesis modules…

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