The University of Bergen (UiB) is an internationally recognised research university. Academic diversity and high quality are fundamental for us. UiB is the most cited university in Norway.
There are seven faculties at UiB and there are close to 18 500 students at the university. Around 2 000 of these are international students. We employ more than 4 000 faculty and staff. PhD candidates are paid employees, making the doctoral degree at UiB particularly attractive for rising talent. About one in three graduating doctors are from outside Norway.
Related Work Packages:
WP1: Precursor and Radiolabeling Methodology
In WP1 “Precursor and Radiolabeling Methodology” we will use contemporary organic synthesis strategies for preparing facile radiolabeling substituents. This will include catalytic functionalization for 18F or 11C labeling, solid supported resin-bound methods and other late stage functionalization strategies. The strategies explored here will also be developed into methods for instrumental radiolabeling using current radiosynthesis modules…
WP2: Metal Chelators and Immuno-PET tracers
Radiolabeling with the promising radionuclide 45Ti and their immobilization on relevant peptides and development of peptide-chelator conjugates for immuno-PET imaging applications will be in focus. We are aiming to implement an efficient method for 45Ti isotope trapping via diol- functionalized resins, subsequently study the decomplexation of resin-bound 45Ti by wrapping the titanium with multidentate and…
WP3: Targeting tyrosine kinases for development of novel selective radioendotheranostics for glioblastoma
This work package will draw the current consortium wide expertise in kinase inhibitors (KIs) and jointly develop small molecule KIs for imaging and treatment of brain tumors. To achieve our goals we will utilize a dual strategy: Development of novel KIs radiolabeled with 11C and 18F and development of novel bioconjugates containing a therapeutic radiometal….
WP4: Tracer Implementation
Development of new tracers takes on average 13 years, similar to other pharmaceuticals. In order to increase patient care and precision diagnostics during the timeframe of this project, much attention will be given to WP4 “Tracer Implementation” to increase the number of locally available PET tracers. Due to the aforementioned costs associated with transport and…